这幅图片显示了两种红血细胞：正常红血细胞(红色背景)和患有镰形细胞贫血症的红血细胞(前景)。

This image shows two red blood cells: a normal red blood cell (colored red in the background) and a red blood cell affected by sickle-cell anemia (in the foreground).

现在，25 %的对疾病的敏感性被归咎于遗传变异。但在镰细胞基因上的变异仅仅参与了其中的一小部分。

It is now known that genetic variability accounts for 25% of susceptibility to the disease, but that variations in the sickle-cell gene contribute to only a fraction of that.

小白鼠的实验表明，关闭镰状贫血症患者的BCL11A基因可以让他们体内产生足够的胎儿血红蛋白，从而降低或消灭疾病症状。

This rodent proof of principle suggests that turning off BCL11A in people with sickle cell disease should allow them to produce enough fetal hemoglobin to reduce or eliminate their symptoms.

There was never a sound beside the wood but one, And that was my long scythe whispering to the ground.

树林边静悄悄，只有一点声音，那是我的长镰在对大地低语。

It's a single gene defect and we know exactly where the genetic defect is in sickle cell.

是一种单基因缺陷,而且我们准确地知道,镰状红细胞贫血的基因缺陷在哪里

My long scythe whispered and left the hay to make.

我的长镰低语，离开一堆堆干草。